| CatalogCode: | NB120-1429 |
| ProductName: | Hsp 90 Antibody |
| Product Description: | Mouse Monoclonal anti-Hsp 90 (S88) |
| Clone: | S88 |
| Clonality: | Monoclonal |
| Immunogen: | Full length native protein (purified) (Achlya ambisexualis). |
| Specificity: | The antibody recognizes a 90 kDa protein, corresponding to the apparent molecular weight of Hsp90 on SDS-PAGE immunoblots. This antibody detects both Hsp90 alpha and beta. |
| CrossReactivity: | Cross-reacts with Chicken, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Sheep and Monkey. Not yet tested in other species. |
| Packaging: | 0.05 mg Whole antisera Mouse ascites. |
| Localization: | Cytoplasmic |
| Background: | In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and Hsp90b which are encoded by separate genes. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steriod receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS pH7.2 with 50% glycerol, 1% BSA |
| ListPrice: | 325 |
| AppSummary: | IP, WB, IHC-Fr |
| SpeciesSummary: | Bv, Ca, Ch, Hu, Mu, Po, Mk, Rt, Rb, Gp, Sh |
| ALTnames: | anti-D6S182 antibody, anti-FLJ26984 antibody, anti-FLJ31884 antibody, anti-heat shock 90kDa protein 1 alpha antibody, anti-Heat shock protein 90kDa alpha cytosolic class A member 1 antibody, anti-Heat shock protein 90kDa alpha cytosolic class B member 1 antibody, anti-Heat shock protein HSP 90 alpha antibody, anti-Heat shock protein HSP 90 beta antibody, anti-HSP 84 antibody, anti-HSP 86 antibody, anti-Hsp 90 antibody, anti-HSP84 antibody, anti-HSP86 antibody, anti-Hsp89 antibody, anti-Hsp90 antibody, anti-HSP90 Beta antibody, anti-HSP90A antibody, anti-HSP90AA1 antibody, anti-HSP90AB1 antibody, anti-HSP90B antibody, anti-HSP90N antibody, anti-HSPC1 antibody, anti-HSPC2 antibody, anti-HSPCA antibody, anti-HSPCAL1 antibody, anti-HSPCAL4 antibody, anti-HSPCB antibody, anti-HSPN antibody, anti-LAP2 antibody, anti-Lipopolysaccharide associated protein2 antibody, anti-LPS associated protein 2 antibody, anti-NY REN 38 antigen antibody |
| ProteinTarget: | Hsp 90 |
| PackageSize: | 0.05 mg |
| GeneralRef: | This product has been used in:Riehl RM et al. Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species. Biochemistry 24:6586-91 (1985). Sanchez ER et al. Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein. J Biol Chem 260:12398-401 (1985). |
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