| CatalogCode: | NB120-14285 |
| ProductName: | c-Fos Antibody |
| Product Description: | Chicken Polyclonal anti-c-Fos |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: corresponding to amino acids 168-380 of Human c-Fos. |
| CrossReactivity: | Cross-reacts with Human, Mouse, Rat and Bovine. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken antisera. |
| Uses: | WB: Predicted molecular weight: 46 kDa. |
| Localization: | Nuclear |
| Background: | The Fos gene family consists of 4 members: Fos, FosB, FosL1, and FosL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP1. As such, the Fos proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the Fos gene has also been associated with apoptotic cell death. The human oncogene c-Fos is homologous to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene. Fos was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. Fos protein is routinely used as a marker of neuronal activation. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Bv, Hu, Mu, Rt |
| ALTnames: | anti-AP1 antibody, anti-V-Jun antibody |
| ProteinTarget: | c-Fos |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Zhang J et al. c-fos regulates neuronal excitability and survival. Nat Genet 30:416-20 (2002). |
| NotesMain: | During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 uL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. |