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| Catalog Code: | NB120-14276 |
| Product Name: | TLR7 Antibody |
| Product Description: | Chicken Polyclonal anti-TLR7 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | Amino acids 871-1020 of TLR7. |
| Cross Reactivity: | Cross-reacts with Human and Mouse.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY |
| Uses: | WB: Use at a dilution of 1/2000. Predicted molecular weight: 116 kDa.Tissue or cell immunostaining: Use at a starting dilution of 1/200.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type I membrane protein (By similarity). |
| Background: | The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL 1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1 10) have been described. Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host Name: | Chicken |
| Buffer: | PBS |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu, |
| Alternate Names: | anti-PRO285 antibody, anti-TLR 7 antibody, anti-Toll like receptor 7 antibody, anti-UNQ248 antibody |
| Package Size: | 0.05 mg |
| Preservative: | none |
| General References: | General / background references:Kadowaki N et al. Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells. J Exp Med 193:1221-6 (2001). Kadowaki N et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 194:863-9 (2001). |
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more information: | company product webpage |