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| Catalog Code: | NB120-14260 |
| Product Name: | RGS17 Antibody |
| Product Description: | Chicken Polyclonal anti-RGS17 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 21361405 |
| Gene Symbol: | RGS17 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide: LTVRNEERGE NAGRPTHTTK MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE, corresponding to amino acids 41-100 of RGS17. |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Rat. Expected to cross-react with Chicken (88% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken antisera. |
| Localization: | Membrane |
| Background: | This protein is a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host Name: | Chicken |
| Buffer: | PBS |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-RGS17 antibody, anti-RGSZ2 antibody, anti-RGS-17 antibody, anti-regulator of G-protein signalling 17 antibody |
| Package Size: | 0.05 mg |
| Preservative: | None |
| Notes Main: | During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 uL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. |
| General References: | [1] Mao,H., Zhao,Q., Daigle,M., Ghahremani,M.H., Chidiac,P. and Albert,P.R. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. J Biol Chem. 2004 Jun 18;279(25):26314-22. Epub 2004 Apr 19. [2] Larminie,C., Murdock,P., Walhin,J.P., Duckworth,M., Blumer,K.J., Scheideler,M.A. and Garnier,M. Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. Brain Res Mol Brain Res. 2004 Mar 17;122(1):24-34. [3] Fischer,T., De Vries,L., Meerloo,T. and Farquhar,M.G., et al. Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8270-5. Epub 2003 Jun 25. [4] Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K., Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,, et al. Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics. 2002 Feb;79(2):177-85. [5] Jordan,J.D., Carey,K.D., Stork,P.J. and Iyengar,R., et al. Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. [6] , Ghahremani M.H., Daigle M., Albert P.R. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. [7] , Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., et al. Cloning of human full-length CDSs in BD Creator(TM) system donor vector. [8] , Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., et al. The DNA sequence and analysis of human chromosome 6. [9] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [10] , Puhl H.L. III, Ikeda S.R., Aronstam R.S. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org). |
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