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| Catalog Code: | NB120-14251 |
| Product Name: | Profilin 2 Antibody |
| Product Description: | Chicken Polyclonal anti-Profilin 2 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide. |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY. |
| Uses: | IHC: Use at a dilution of 1/200. WB: Use at a dilution of 1/500. Predicted molecular weight: 17 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoskeleton |
| Background: | Profilin 2 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals by binding to actin (1:1 ratio) and so affecting the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Highly expressed in skeletal muscle, kidney and brain and less strongly in placenta, heart, liver and lung. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host Name: | Chicken |
| Buffer: | PBS |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-D3S1319E antibody, anti-PFL antibody, anti-PFN 2 antibody, anti-PFN2 antibody, anti-Profilin II antibody, anti-Profilin2 antibody, anti-ProfilinII antibody |
| Package Size: | 0.05 mg |
| Preservative: | none |
| Notes Main: | During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 uL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. |
| General References: | General / background references:Gieselmann R et al. Distinct biochemical characteristics of the two human profilin isoforms. Eur J Biochem 229:621-8 (1995). |
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more information: | company product webpage |