| request information: |
|
| Catalog Code: | NB120-14241 |
| Product Name: | CDC42 Antibody |
| Product Description: | Chicken Polyclonal anti-CDC42 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide, corresponding to amino acids 1-191 of CDC42. |
| Specificity: | Ab14241 recognises CDC42 isoform 1. |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY. |
| Uses: | WB: Use at a dilution of 1/2000. Predicted molecular weight: 24 kDa. Tissue or cell immunostaining: Use at a starting dilution of 1/200.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Plasma membrane |
| Background: | This protein is a small GTPase of the Rho subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc42, and is able to complement the yeast cdc42 1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott Aldrich syndrome protein (NWASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in at least two transcript variants. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host Name: | Chicken |
| Buffer: | PBS |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-CDC 42 antibody, anti-CDC42Hs antibody, anti-Cell division control protein 42 homolog antibody, anti-Cell division cycle 42 antibody, anti-Cell division cycle 42 isoform 1 antibody, anti-Cell division cycle 42 isoform 2 antibody, anti-dJ224A6.1.1 antibody, anti-dJ224A6.1.2 antibody, anti-G25K antibody, anti-G25K GTP binding protein antibody, anti-Growth regulating protein antibody, anti-GTP binding protein 25kD antibody, anti-Small GTP binding protein CDC42 antibody |
| Package Size: | 0.05 mg |
| Preservative: | none |
| General References: | General / background references:Etienne-Manneville S & Hall A Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421:753-6 (2003). |
order or
more information: | company product webpage |