| CatalogCode: | NB120-14233 |
| ProductName: | C3IP1 Antibody |
| Product Description: | Chicken Polyclonal anti-C3IP1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: KHAKKEREES LPNLLQYVRM PLLTPRYITD VIDAEPFIRC SLQCRDLVDE AKKFHLRPEL RSQMQGPRTR ARLGANEVLL VVGGFGSQQS PIDVVEKYDP KTQEWSFLPS ITRKRRYVAS VSLHDRIYVI GGYDGRSRLS SVECLDYTAD EDGVWYSVAP MNVRRGLAGA TTLGDMIYVS GGFDGSRRHT SMERYDPNID, corresponding to amino acids 205-404 of Human C3IP1. |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat.Expected to cross-react with Xenopus laevis (92% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken antisera. |
| Uses: | WB: Predicted molecular weight: 68 kDa. Optimal dilutions/concentrations should be determined by the end user. |
| Background: | Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3. Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | IHC, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-KLHL12 antibody, anti-C3IP1 antibody, anti-DKIR antibody, anti-CUL3-interacting protein 1 antibody, anti-Kelch-like 12 antibody |
| ProteinTarget: | C3IP1 |
| PackageSize: | 0.05 mg |