| CatalogCode: | | NB120-14071 |
| ProductName: | | SPARC Antibody |
| Product Description: | | Chicken Polyclonal anti-SPARC |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide, corresponding to amino acids 10-303 of Human SPARC. |
| CrossReactivity: | | Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Packaging: | | 0.1 mg Immunogen affinity purified Chicken antisera. |
| Uses: | | ICC, WB Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | | Secreted |
| Background: | | Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgY |
| Host_Name: | | Chicken |
| Buffer: | | PBS |
| ListPrice: | | 325 |
| AppSummary: | | IF, WB, ICC |
| SpeciesSummary: | | Hu, Mu, Rt |
| ALTnames: | | anti-ON antibody |
| ProteinTarget: | | SPARC |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | General / background references:Gilmour DT et al. Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J 17:1860-70 (1998). |
| more information: | | company product webpage |