| CatalogCode: | NB120-14035 |
| ProductName: | IL16 Antibody |
| Product Description: | Chicken Polyclonal anti-IL16 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: PDLNSSTDSA ASASAASDVS VESTAEATVC TVTLEKMSAG LGFSLEGGKG SLHGDKPLTI NRIFKGAASE QSETVQPGDE ILQLGGTAMQ GLTRFEAWNI IKALPDGPVT IVIRRKSLQS KETTAAGDS, corresponding to amino acids 503-631 of IL16 (Human). |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY |
| Uses: | ELISA: Use at a concentration of 0.1 ug/ml. WB: Use at an assay dependent dilution. Predicted molecular weight: 70 kDa.Tissue or cell immunostaining: Use at an assay dependent dilution.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Secreted |
| Background: | IL16 is a proinflammatory cytokine that is chemotactic for CD4+ T lymphocytes, monocytes, and eosinophils. IL16 is synthesized as a precursor molecule (pro IL16) of approximately 68 kDa and 631 amino acid residues lacking a signal peptide. The sequence and structure of IL16 is conserved across species. In addition to inducing chemotaxis, IL16 upregulates the IL2 receptor and upregulates HLADR expression. It also inhibits T cell receptor (TCR)/CD3 dependent activation, and suppresses HIV1 replication in vitro. Sources of IL16 include epithelial cells, mast cells, T lymphocytes (CD4+ and CD8+), macrophages, synovial fibroblasts, and eosinophils. |
| Storage: | 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-HGNC:5980 antibody, anti-HsT19289 antibody, anti-Interleukin 16 precursor antibody, anti-LCF antibody, anti-Lymphocyte chemoattractant factor antibody, anti-PrIL16 antibody |
| ProteinTarget: | IL16 |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Qi JC et al. IL-16 regulation of human mast cells/basophils and their susceptibility to HIV-1. J Immunol 168:4127-34 (2002). |