| CatalogCode: | NB120-14020 |
| ProductName: | Estrogen Receptor Antibody |
| Product Description: | Chicken Polyclonal anti-Estrogen Receptor |
| Clonality: | Polyclonal |
| Immunogen: | Fusion protein: IRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA DRELVHMINW AKRVPGF, corresponding to amino acids 255-367 of Human Estrogen Receptor. |
| CrossReactivity: | Cross-reacts with Human.Expected to cross-react with Mouse (89% identity with immunogen), Rat (89% identity with immunogen), Cow (88% identity with immunogen) and Hamster (87% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY. |
| Uses: | WB: Use at a dilution of 1/500 - 1/2000. Detects a band of approximately 66 kDa (predicted molecular weight: 66 kDa). Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Background: | Estrogen Receptor alpha is a 65 kDa protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation. Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies |
| Storage: | 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-DKFZp686N23123 antibody, anti-ER alpha antibody, anti-ER antibody, anti-Era antibody, anti-ESR 1 antibody, anti-ESR antibody, anti-ESR1 antibody, anti-ESRA antibody, anti-Estradiol receptor antibody, anti-Estrogen receptor 1 antibody, anti-Estrogen receptor antibody, anti-Major ORF antibody, anti-NR3A1 antibody |
| ProteinTarget: | Estrogen Receptor |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Fan S et al. BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science 284:1354-6 (1999). |
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