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| Catalog Code: | NB120-13999 |
| Product Name: | BAF53A Antibody |
| Product Description: | Chicken Polyclonal anti-BAF53A |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | Recombinant fragment, corresponding to amino acids 1-429 of Human BAF53A. |
| Specificity: | Cross reacts with BAF53b. |
| Cross Reactivity: | Cross-reacts with Human and Mouse.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken IgY |
| Uses: | IHC: Use at a dilution of 1/500. WB: Use at a dilution of 1/1000. Predicted molecular weight: 47 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Background: | This protein is a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This protein is a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. |
| Storage: | 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host Name: | Chicken |
| Buffer: | PBS |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Hu, Mu, |
| Alternate Names: | anti-53 kDa BRG1 associated factor A antibody, anti-Actin related protein Baf53a antibody, anti-BRG1/brm associated factor 53A antibody |
| Package Size: | 0.05 mg |
| Preservative: | none |
| General References: | General / background references:Zhao K et al. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 95:625-36 (1998). |
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