| CatalogCode: | | NB120-13989 |
| ProductName: | | beta 2 Adrenergic Receptor Antibody |
| Product Description: | | Chicken Polyclonal anti-beta 2 Adrenergic Receptor |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide: DFRIAFQELLC LRRSSLKAYGN GYSSNGNTGE QSGYHVEQEKE NKLLCEDLPGT EDFVGHQGTVP SDNIDSQGRNCS T, corresponding to amino acids 335-408 of Human beta 2 Adrenergic Receptor. |
| CrossReactivity: | | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | | 0.05 mg Affinity purified Chicken antisera. |
| Uses: | | IHC: Use at a dilution of 1/200. WB: Use at a dilution of 1/500. Predicted molecular weight: 46.5 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | | Cell Membrane |
| Background: | | This protein is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This protein contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | Affinity purified |
| Isotype: | | IgY |
| Host_Name: | | Chicken |
| Buffer: | | Preservative: NoneConstituents: PBS |
| ListPrice: | | 285 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-ADRB2 antibody |
| ProteinTarget: | | beta 2 Adrenergic Receptor |
| PackageSize: | | 0.05 mg |
| GeneralRef: | | 1. Zee,R.Y., Cook,N.R., Cheng,S., Erlich,H.A., Lindpaintner,K. and Ridker,P.M. Polymorphism in the beta2-adrenergic receptor and lipoprotein lipase genes as risk determinants for idiopathic venous thromboembolism: a multilocus, population-based, prospective genetic analysis. Circulation. 2006 May 9;113(18):2193-200. Epub 2006 May 1. 2. McGraw,D.W., Mihlbachler,K.A., Schwarb,M.R., Rahman,F.F., Small,K.M., Almoosa,K.F. and Liggett,S.B. Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. J Clin Invest. 2006 May;116(5):1400-9. 3. Sotoodehnia,N., Siscovick,D.S., Vatta,M., Psaty,B.M., Tracy,R.P., Towbin,J.A., Lemaitre,R.N., Rea,T.D., Durda,J.P., Chang,J.M.,, et al. Beta2-adrenergic receptor genetic variants and risk of sudden cardiac death. Circulation. 2006 Apr 18;113(15):1842-8. 4. Park,J.S., Zhang,S.Y., Jo,S.H., Seo,J.B., Li,L., Park,K.W., Oh,B.H., Park,Y.B. and Kim,H.S. Common adrenergic receptor polymorphisms as novel risk factors for vasospastic angina. Am Heart J. 2006 Apr;151(4):864-9. 5. Spijker,P., Vaidehi,N., Freddolino,P.L., Hilbers,P.A. and Goddard,W.A. III. Dynamic behavior of fully solvated beta2-adrenergic receptor, embedded in the membrane with bound agonist or antagonist. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4882-7. Epub 2006 Mar 21. 6. Kobilka B.K., Dixon R.A.F., Frielle T., Dohlman H.G., Bolanowski M.A., Sigal I.S., Yang-Feng T.L., Francke U., Caron M.G., Lefkowitz R.J., et al. cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. PNAS January 1, 1987 vol. 84 no. 1 46-50. 7. Emorine L.J., Marullo S., Delavier-Klutchko C., Kaveri S.V., Durieu-Trautmann O., Strosberg A.D. Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization. PNAS October 15, 1987 vol. 84 no. 20 6995-6999. 8. Kobilka B.K., Frielle T., Dohlman H.G., Bolanowski M.A., Dixon R.A.F., Keller P., Caron M.G., Lefkowitz R.J. Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. J. Biol. Chem., Vol. 262, Issue 15, 7321-7327, 05, 1987. |
| more information: | | company product webpage |
|