| CatalogCode: | NB120-13485 |
| ProductName: | CTLA4 Antibody |
| Product Description: | Mouse Monoclonal anti-CTLA4 (AS32) |
| Clone: | AS32 |
| Clonality: | Monoclonal |
| Immunogen: | Purified recombinant extracellular domain of human CTLA4 |
| Epitope: | NB 120-13485 recognizes the extracellular domain of CTLA4. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.025 mg protein G purified Mouse ascites. |
| Uses: | Neut: Use at an assay dependent dilution. NB 120-13485 has been shown to block the interaction of soluble human CTLA4 with human CD80. |
| Localization: | Type I membrane protein. |
| Background: | CD152 and CD28, structurally similar molecules, are members of the immunoglobin (Ig) gene superfamily. They are composed of a single Ig V-like extracellular domain, a transmembrnne domain, and an intracellular domain. CD152, a cell surface glycoprotein, was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. CD152 (CTLA-4) and CD28 are receptors for the ligands, CD80 (B7-1) and CD86 (B7-2).2, 3 CD152 and CD28 together with their ligands constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. CD152 acts as a co-stimulatory molecule in eliciting T cell help during antigen presentation and functions as a negative regulator of T cell activation.4, 5 CD152 is expressed on most T lymphocytes. The level of expression is activation-dependent.6 The genes encoding human CD152 and CD28 are closely linked on chromosome 2. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS |
| ListPrice: | 325 |
| AppSummary: | CA |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CD152 antibody |
| ProteinTarget: | CTLA4 |
| PackageSize: | 0.025 mg |
| GeneralRef: | 1. Harper, K., et al., J. Immunol. 147, 1037 (1991). 2. Murakami, M., et al., Proc. Natl. Acad. Sci. USA, 93, 7838 (1996). 3. Gribben, J.G., et al., Proc. Natl. Acad. Sci. USA, 92, 811 (1995). 4. Karandikar, N.J., et al., J. Exp. Med., 184, 783 (1996). 5. Walunas, T.L., et al., Immunity, 1, 405 (1994). 6. Lindsten, T., et al. J. Immunol., 151, 3489 (1993). |
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