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| Catalog Code: | NB120-13262 |
| Product Name: | Syntaxin Antibody |
| Product Description: | Rabbit Polyclonal anti-Syntaxin |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide: MKDRTQELRTAKDSDDDDD conjugated to KLH, corresponding to amino acids 1-19 of Human Syntaxin. |
| Cross Reactivity: | Expected to cross-react with Human (100% identity with immunogen), Rat (100% identity with immunogen), Mouse (100% identity with immunogen), Zebrafish (100% identity with immunogen) and Chicken (94% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.05 mg protein A purified Rabbit IgG. |
| Uses: | WB: Use at a concentration of 1 ug/ml. Detects a band of approximately 35-36 kDa (predicted molecular weight: 34.6 kDa). Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type IV membrane protein. |
| Background: | Syntaxin 1a is potentially involved in docking of synaptic vesicles at presynaptic active zones and may play a critical role in neurotransmitter exocytosis. Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculo skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS, pH 7.2, 50% glycerol |
| Application Summary: | Western Blot |
| Species Summary: | Mu, Rt, |
| Alternate Names: | anti-Neuron specific antigen HPC1 antibody, anti-STX1A antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.09% azide |
| General References: | General / background references:Aguado F et al. Syntaxin 1A and 1B display distinct distribution patterns in the rat peripheral nervous system. Neuroscience 88:437-46 (1999). Risinger C & Bennett MK Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms. J Neurochem 72:614-24 (1999). Shuang R et al. Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings. J Biol Chem 273:4957-66 (1998). |
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