| CatalogCode: | NB120-13261 |
| ProductName: | Syntaxin 13 Antibody |
| Product Description: | Mouse Monoclonal anti-Syntaxin 13 (15G2) |
| Clone: | 15G2 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant full length protein (Rat). |
| CrossReactivity: | Cross-reacts with Mouse, Rat, Dog and Hamster. Not yet tested in other species. |
| Packaging: | 0.05 mg protein G purified Mouse ascites. |
| Uses: | WB: Detects a band of approximately 38 kDa. Additional bands of 27 and 37 kDa may also be recognized, and are believed to correspond to degradation products of syntaxin 13. |
| Localization: | Tubular early and recycling endosomes and endosomal vacuoles. |
| Control: | Rat or Mouse Brain Tissue Extract. |
| Background: | Syntaxin 13 is an integral membrane protein that belongs to the t-SNARE family, a group of proteins involved in protein transport. Confocal immunofluoresence and electron microscopy studies have shown that syntaxin 13 is primarily localized to tubular early and recycling endosomes, where it colocalizes with transferrin receptor, and it is also localized in endosomal vacuoles. Syntaxin 13 has been found to be expressed in all tissues, with higher levels of the protein found in brain, lung, spleen, thymus and testes. Immunoprecipitation studies show that syntaxin 13 complexes with beta-SNAP, VAMP2/3, and SNAP25. The binding of this complex to alpha-SNAP and NSF is terminated in the presence of ATP. These results suggest that syntaxin 13 is a SNARE protein which mediates the recycling protein flow through tubulo vesicular recycling endosomes. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Mouse |
| Buffer: | 50% Glycerol, PBS, 0.1mM PMSF |
| ListPrice: | 295 |
| AppSummary: | WB, ICC |
| SpeciesSummary: | Ca, Ha, Mu, Rt |
| ALTnames: | anti-CG11278 antibody, anti-CT31479 antibody, anti-Dm Syx13 antibody, anti-DmSyx13 antibody, anti-ff16 (69D1-70A2) antibody, anti-ff16 antibody, anti-l(3)01470 antibody, anti-Syntaxin13 antibody, anti-Syx 13 antibody, anti-Syx13 antibody |
| ProteinTarget: | Syntaxin 13 |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Huang L et al. The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency. Nat Genet 23:329-32 (1999). Advani RJ et al. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. J Biol Chem 273:10317-24 (1998). Prekeris R et al. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J Cell Biol 143:957-71 (1998). |
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