| CatalogCode: | NB120-13091 |
| ProductName: | Prostaglandin E Receptor EP2 Antibody |
| Product Description: | Rabbit Polyclonal anti-Prostaglandin E Receptor EP2 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human) conjugated to KLH. |
| Epitope: | Third extracellular domain |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.025 mg Immunogen affinity purified Rabbit IgG. |
| Uses: | IHC-P: Use at a dilution of 1/100 - 1/200. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Background: | Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. Prostaglandin E2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo Prostaglandin E2 induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.01% Sodium Azide Constituents: PBS. pH 7.7 |
| ListPrice: | 285 |
| AppSummary: | IHC-P |
| ALTnames: | anti-15 hydroxyprostaglandin dehydrogenase [NAD+] antibody, anti-15 PGDH antibody, anti-HPGD antibody, anti-PGDH antibody, anti-PGDH1 antibody anti-EP 2 antibody, anti-EP2 antibody, anti-Human prostaglandin E2 receptor antibody, anti-PGE receptor EP2 subtype antibody, anti-Prostaglandin E receptor 2 EP2 subtype antibody, anti-Prostaglandin E receptor 2 subtype EP2 53kDa antibody, anti-Prostaglandin E receptor 2 subtype EP2 antibody, anti-Prostaglandin E2 receptor EP2 subtype antibody, anti-Prostanoid EP2 receptor antibody, anti-PTGER 2 antibody, anti-PTGER2 antibody |
| ProteinTarget: | Prostaglandin E Receptor EP2 |
| PackageSize: | 0.025 mg |