| request information: |
|
| Catalog Code: | NB120-11884 |
| Product Name: | C5R1 Antibody |
| Product Description: | Mouse Monoclonal anti-C5R1 (W17/1) |
| Clone: | W17/1 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 0.1 mg/ml |
| Immunogen: | Unfortunately, this information is considered to be commercially sensitive, (extracellular domain of the N-terminus). |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.05 mg protein G purified Mouse ascites. |
| Uses: | Not suitable for IP. Suggested starting working dilution 1/10. |
| Localization: | Integral membrane protein. |
| Background: | The human anaphylatoxin C5a is a 74-residue glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a could be demonstrated, rendering this molecule an important mediator of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTPbinding-protein-coupled receptor that belongs to the rhodopsin supergene family. The C5a receptor is approximately 45 kDa. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS, 0.1% BSA |
| Application Summary: | flow cytometry / FACS analysis , immunohistochemistry , immunoprecipitation (-) |
| Species Summary: | Hu, |
| Alternate Names: | anti-C5A antibody, anti-C5AR antibody, anti-CD88 antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% Sodium Azide |
| General References: | General / background references:Oppermann M & Götze O Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors. Immunology 82:516-21 (1994). Oppermann M et al. Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain. J Immunol 151:3785-94 (1993). |
order or
more information: | company product webpage |