| CatalogCode: | NB120-11867 |
| ProductName: | C5R1 Antibody |
| Product Description: | Mouse Monoclonal anti-C5R1 (S5/1) |
| Clone: | S5/1 |
| Clonality: | Monoclonal |
| Immunogen: | This antibody was raised against a synthetic peptide derived from the N-terminus of C5aR (Met1-Asn31, amino acids 1-31). |
| Specificity: | The antibody has been shown to inhibit the binding of C5a to its receptor. |
| CrossReactivity: | Cross-reacts with Human. |
| Packaging: | 0.05 mg protein G purified Mouse ascites. |
| Uses: | FACS: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. Inhib: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 45 kDa (predicted molecular weight: 42 kDa). Is unsuitable for IHC-Fr or IP.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Integral membrane protein. |
| Background: | The human anaphylatoxin C5a is a 74 residue glycopeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a can be demonstrated, rendering this molecule an important mediartor of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP binding coupled receptor that belongs to the rhodopsin supergene family. C5a receptor 1 expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. ESTs have been isolated from B cell/lung/testis, nerve, and placenta libraries. |
| ProductRef: | 1. Oppermann M et al. Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. J. Immunol 1993, 151:3785 2. Oppermann, M et al. Antibodies from the myeloid panel that react with the C5a receptor and antagonize C5a biological activity. Schlossman, S.F. (ed.) Leucocyte typing V.O.U.P.:955-95 |
| Storage: | Store at 4 degrees C long term. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | 0.1% BSA with PBS |
| ListPrice: | 325 |
| AppSummary: | FACS, WB, IHC-P, CA |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-ANAPHYLATOXIN RECEPTOR antibody, Anti-C5a anaphylatoxin chemotactic receptor antibody, Anti-C5a ligand antibody, Anti-C5aR antibody, Anti-C5R1 antibody, Anti-CD88 antibody, Anti-CD88 antigen antibody, Anti-Complement component 5 receptor 1 antibody, Anti-Complement component 5 receptor 2 antibody |
| ProteinTarget: | C5R1 |
| PackageSize: | 0.05 mg |
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