| CatalogCode: | NB120-11823 |
| ProductName: | LAP2 Antibody |
| Product Description: | Mouse Monoclonal anti-LAP2 (6E10) |
| Clone: | 6E10 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide: GEQRKDVYVQLYLQHLTARNRP, corresponding to amino acids 29-50 of Human LAP2, common to all isoforms. |
| Epitope: | The epitope recognized by the antibody resides within the N-terminus (amino acids 29-50), common to all human and mouse LAP2/TMPOs |
| CrossReactivity: | Cross-reacts with Human.Expected to cross-react with Mouse (100% identity with immunogen), Rat (100% identity with immunogen), Xenopus laevis (90% identity with immunogen) and Cow (88% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 ml purified Mouse IgG. |
| Uses: | IHC-P: Use at an assay dependent dilution. WB: Use at a concentration of 2 - 4 ug/ml. Detects bands of approximately 76 (alpha), 50 (beta, singlet or doublet), 45 (epsilon), 42 (delta), 38 (gamma, singlet or doublet) and 25 kDa (zeta). Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear and Secreted |
| Control: | Whole extract of cultured human chronic myelogenous leukemia K562 cells. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Preservative: 15mM Sodium Azide Constituents: 0.01M PBS. pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | IHC-P, WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | LAP2 |
| PackageSize: | 0.1 ml |
| GeneralRef: | General / background references:Nili E et al. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci 114:3297-307 (2001). Alsheimer M et al. Architecture of the nuclear periphery of rat pachytene spermatocytes: distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sites. Mol Biol Cell 10:1235-45 (1999). Goldberg M et al. The nuclear lamina: molecular organization and interaction with chromatin. Crit Rev Eukaryot Gene Expr 9:285-93 (1999). |