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| Catalog Code: | NB120-11462 |
| Product Name: | CD130 Antibody |
| Product Description: | Mouse Monoclonal anti-CD130 (B-T2) |
| Clone: | B-T2 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 1 mg/ml |
| Immunogen: | Natural soluble gp130 receptor (Human). |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Mouse IgG. |
| Uses: | ELISA: Use at an assay dependent dilution. FACS: Use 0.2ug for 10<sup>6</sup> cells. Use 10µl of the suggested working dilution to label 10<sup>6</sup> cells in 100µl.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type I membrane (isoform 1). Secreted (isoform 2). |
| Background: | CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS |
| Application Summary: | ELISA, flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | anti-CDw130 antibody, anti-Interleukin 6 signal transducer antibody, anti-CD 130 antibody, anti-CD130 antibody, anti-CD130 antigen antibody, anti-CDw130 antibody, anti-gp130 antibody, anti-gp130 of the rheumatoid arthritis antigenic peptide bearing soluble form antibody, anti-GP130 RAPS antibody, anti-gp130 transducer chain antibody, anti-GP130-RAPS antibody, anti-IL 6R beta antibody, anti-IL6 ST antibody, anti-IL6R beta antibody, anti-IL6R-beta antibody, anti-IL6Rbeta antibody, anti-IL6ST antibody, anti-IL6ST nirs antibody, anti-IL6ST nirs variant antibody, anti-Interleukin 6 receptor beta chain antibody, anti-Interleukin 6 receptor subunit beta antibody, anti-Interleukin 6 signal transducer antibody, anti-Interleukin receptor beta chain antibody, anti-Membrane glycoprotein 130 antibody, anti-Membrane glycoprotein gp130 antibody, anti-Oncostatin M receptor antibody, anti-Oncostatin M receptor alpha subunit antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.09% Sodium Azide |
| Notes Main: | This product should be stored undiluted.Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch. |
| General References: | General / background references:Wijdenes J et al. Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. Eur J Immunol 25:3474-81 (1995). |
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