| CatalogCode: | NB120-11269 |
| ProductName: | Stathmin 1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Stathmin 1 |
| Clonality: | Polyclonal |
| Immunogen: | synthetic peptide corresponding to a sequence of human Op-18/Stathmin (amino acids 132-149 with N-terminally added Cys-Gly), conjugated to maleimide activated-KLH. |
| Specificity: | The immunogen sequence is not found in other members of the Stathmin family such as SCG10, RB3, and XB3. |
| CrossReactivity: | Cross-reacts with Human and Rat.Expected to cross-react with Mouse due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | IHC-P: Use at a dilution of 1/500. This concentration was determined for sections of human tonsil. WB: Use at a dilution of 1/2000. Staining of Stathmin in WB is specifically inhibited with Stathmin immunizing peptide. Detects a band of approximately 19 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Control: | Whole cell extract of the human acute lymphoma Jurkat cell line.Cytosolic fraction of rat brain.Huma |
| Background: | This protein is a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 15mM Sodium Azide Constituents: 0.01M PBS. pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | IHC-P, WB |
| ALTnames: | anti-Lag antibody, anti-LAP 18 antibody, anti-LAP18 antibody, anti-Leukemia associated phosphoprotein p18 antibody, anti-Metablastin antibody, anti-Oncoprotein 18 antibody, anti-OP 18 antibody, anti-OP18 antibody, anti-p18 antibody, anti-p19 antibody, anti-Phosphoprotein 19 antibody, anti-Phosphoprotein p19 antibody, anti-PP17 antibody, anti-PP19 antibody, anti-PR22 antibody, anti-Pr22 protein antibody, anti-Prosolin antibody, anti-Protein Pr22 antibody, anti-SMN antibody, anti-Stathmin antibody, anti-Stathmin1 antibody, anti-STMN 1 antibody, anti-STMN1 antibody |
| ProteinTarget: | Stathmin 1 |
| PackageSize: | 0.1 ml |
| GeneralRef: | General / background references:Sobel A Stathmin: a relay phosphoprotein for multiple signal transduction? Trends Biochem Sci 16:301-5 (1991). Hailat N et al. N-myc gene amplification in neuroblastoma is associated with altered phosphorylation of a proliferation related polypeptide (Op18). Oncogene 5:1615-8 (1990). Koppel J et al. Developmental tissue expression and phylogenetic conservation of stathmin, a phosphoprotein associated with cell regulations. J Biol Chem 265:3703-7 (1990). Doye V et al. A single cDNA encodes two isoforms of stathmin, a developmentally regulated neuron-enriched phosphoprotein. J Biol Chem 264:12134-7 (1989). |
| NotesMain: | Storage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours. |
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