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| Catalog Code: | NB120-10537 |
| Product Name: | Cdc25C Antibody |
| Product Description: | Mouse Monoclonal anti-Cdc25C (DCS-193) |
| Clone: | DCS-193 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant full length protein (Human). |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.05 ml Mouse ascites. |
| Uses: | WB: Use at a dilution of 1/1000. Detects a band of approximately 65 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Background: | Cdc25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It has been highly conserved during evolution and it plays a key role in the regulation of cell division. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Cdc25C is mainly expressed in G2 phase. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. |
| Storage: | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | Preservative: 15mM Sodium Azide |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-CDC 25 antibody, anti-Cdc 25C antibody, anti-CDC25 antibody, anti-Cell division cycle 25 homolog C antibody, anti-Cell Division Cycle 25C antibody, anti-Dual specificity phosphatase Cdc25C antibody, anti-M phase inducer phosphatase 3 antibody, anti-Mitosis inducer CDC25 antibody, anti-MPIP3 antibody, anti-Phosphotyrosine phosphatase antibody |
| Package Size: | 0.05 ml |
| Preservative: | 15 mM sodium azide |
| General References: | General / background references:Lammer C et al. The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J Cell Sci 111 ( Pt 16):2445-53 (1998). Freeman RS & Donoghue DJ Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle. Biochemistry 30:2293-302 (1991). Pines J & Hunter T Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol 115:1-17 (1991). |
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