| CatalogCode: | | NB120-10535 |
| ProductName: | | Cdc7 Kinase Antibody |
| Product Description: | | Mouse Monoclonal anti-Cdc7 Kinase (DCS-341) |
| Clone: | | DCS-341 |
| Clonality: | | Monoclonal |
| Immunogen: | | full-length human Cdc7 kinase. |
| CrossReactivity: | | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | | 0.5 ml |
| Uses: | | ELISA: Use at an assay dependent dilution. ICC: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a concentration of 0.4 ug/ml. Detects a band of approximately 55 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | | Nuclear |
| Background: | | DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. The activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins). Cdc7 kinase was also found to be important in meiosis, checkpoint responses, maintenance of chromosome structure, and repair. |
| Storage: | | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Isotype: | | IgG1 |
| Host_Name: | | Mouse |
| Buffer: | | Preservative: 15mM Sodium AzideConstituents: 0.01M PBS. pH 7.4 |
| ListPrice: | | 285 |
| AppSummary: | | ELISA, ICC, IP, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-Cdc 7 antibody, anti-Cdc7 antibody, anti-CDC7 cell division cycle 7 antibody, anti-CDC7 cell division cycle 7 like 1 antibody, anti-CDC7 L1 antibody, anti-Cdc7 like 1 antibody, anti-CDC7 related kinase antibody, anti-CDC7L 1 antibody, anti-CDC7L1 antibody, anti-Cell division cycle 7 homolog antibody, anti-Cell Division Cycle 7 Kinase antibody, anti-Cell division cycle 7 like protein 1 antibody, anti-Cell division cycle 7 related protein kinase antibody, anti-HsCDC7 antibody, anti-Hsk1 antibody, anti-HuCDC 7 antibody, anti-MGC117361 antibody, anti-MGC126237 antibody, anti-MGC126238 antibody |
| ProteinTarget: | | Cdc7 Kinase |
| PackageSize: | | 0.05 ml |
| GeneralRef: | | General / background references:Masai H & Arai K Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J Cell Physiol 190:287-96 (2002). Lei M & Tye BK Initiating DNA synthesis: from recruiting to activating the MCM complex. J Cell Sci 114:1447-54 (2001). Jares P et al. The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint? EMBO Rep 1:319-22 (2000). |
| more information: | | company product webpage |
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