| Catalog Code: | NB120-10529 |
| Product Type: | Primary Antibody |
| Product Name: | c-Abl Antibody |
| List Price: | 330 |
| Clonality: | Polyclonal |
| Gene ID: | 25 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-c-Abl |
| Cross Reactivity: | Cross-reacts with Human and Mouse.Does not cross-react with Rat.Not yet tested in other species. |
| Species Summary: | Hu, Mu, Rt (-) |
| Background: | Protein tyrosine kinases play important roles in the transduction of extracellular signals. Receptor tyrosine kinases include a myriad of growth factor receptors, which are activated upon ligand binding. Differential binding of adapter proteins may impart |
| Immunogen: | Synthetic peptide: YISDEVEKELG (Human). |
| Localization: | Cytoplasmic and Nuclear |
| Specificity: | Anti-c-Abl is detects both c- and v-Abl encoded proteins as well as p210 and p190 c-Abl forms in CML and ALL cells, respectively. The antibody does not inhibit the activity of Abl protein-tyrosine kinase. |
| Purity: | IgG purified |
| Buffer: | Preservative: 0.1% Sodium AzideConstituents: 0.05M PBS0.2% Gelatin |
| Packaging: | 50 micrograms |
| Package Size: | 0.05 mg |
| Concentration: | 0.1 mg/ml |
| Uses: | IF: Use at a concentration of 1 - 5 ug/ml. IP: Use 1ug for 10<sup>2</sup> cells.WB: Use at a concentration of 1 - 5 ug/ml. Detects a band of approximately 120 kDa. Not tested in other applications.Optimal dilutions/concentrations should be det |
| Application Summary: | IF, IP, WB |
| General References: | General / background references:Der CJ Cellular oncogenes and human carcinogenesis. Clin Chem 33:641-6 (1987). Stam K et al. Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromo |