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| Catalog Code: | NB120-10527 |
| Product Name: | CD40 Antibody |
| Product Description: | Mouse Monoclonal anti-CD40 (82105) |
| Clone: | 82105 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | purified recombinant human CD40, extracellular domain expressed in NSO cells. |
| Cross Reactivity: | Cross-reacts with Human.Does not cross-react with Mouse.Not yet tested in other species. |
| Packaging: | 0.1 mg |
| Uses: | ELISA: Use at a concentration of 0.5 - 1.0 ug/ml. WB: Use at a concentration of 1 - 2 ug/ml. Detects a band of approximately 50 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type I membrane protein (isoforms I, III, IV and V); secreted (isoform II). |
| Background: | CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin. |
| Isotype: | IgG2b |
| Host Name: | Mouse |
| Buffer: | Preservative: None Constituents: PBS |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu, Mu(-) |
| Alternate Names: | anti-Bp50 antibody, anti-CDW40 antibody, anti-MGC9013 antibody, anti-TNFRSF5 antibody, anti-p50 antibody |
| Package Size: | 0.1 mg |
| General References: | General / background references:van Kooten C & Banchereau J CD40-CD40 ligand. J Leukoc Biol 67:2-17 (2000). van Kooten C & Banchereau J Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Immunol 9:330-7 (1997). Foy TM et al. Immune regulation by CD40 and its ligand GP39. Annu Rev Immunol 14:591-617 (1996). |
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