| CatalogCode: | NB120-10525 |
| ProductName: | DCC Antibody |
| Product Description: | Goat Polyclonal anti-DCC |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant fragment (Human). |
| Specificity: | The antibody can be used in neutralization of receptor-ligand interaction. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.025 mg |
| Uses: | ELISA: Use at a concentration of 0.5 - 1.0 ug/ml. Neut: Use at a concentration of 2 ug/ml. WB: Use at a concentration of 0.1 - 0.2 ug/ml. Predicted molecular weight: 31 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Plasma membrane |
| Background: | Deleted in colorectal cancer (DCC, chromosome 18q21) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The gene has also been deleted in several other types of cancer. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. The extracellular domain is composed of four Ig-like domains and six fibronectin type III repeats. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Mouse DCC extracellular domain shares 97% and 99% homology with human and rat DCC extracellular domains, respectively. In adults, DCC is highly expressed in the brain but is also expressed at very low levels in multiple normal tissues. In the embyro, high levels of expression are detected in the brain and neural tube. DCC functions as a receptor or a component of a receptor for netrins and mediates the effects of netrins on commissural axons. Netrins are chemoattractants responsible for the guidance of commissural axons at the midline and of motor axons to the their target muscles. DCC induces apoptosis in the absence of ligand binding, blocks apoptosis when engaged by netrin 1, and also acts as a caspase substrate. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | phosphate buffered saline containing 5% trehalose Preservative: None |
| ListPrice: | 285 |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Colorectal cancer related chromosome sequence 18 antibody, anti-Colorectal cancer suppressor antibody, anti-CRC 18 antibody, anti-CRC18 antibody, anti-CRCR 1 antibody, anti-CRCR1 antibody, anti-Deleted in colorectal cancer protein antibody, anti-Deleted in colorectal carcinoma antibody, anti-Netrin receptor DCC antibody, anti-Tumor suppressor protein DCC antibody |
| ProteinTarget: | DCC |
| PackageSize: | 0.025 mg |
| GeneralRef: | General / background references:Huerta S et al. Human colon cancer cells deficient in DCC produce abnormal transcripts in progression of carcinogenesis. Dig Dis Sci 46:1884-91 (2001). Cooper HM et al. Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. Oncogene 11:2243-54 (1995). Fearon ER et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247:49-56 (1990). |