| CatalogCode: | NB120-1048 |
| ProductName: | CD50 Antibody |
| Product Description: | Mouse Monoclonal anti-CD50 (MEM-171) |
| Clone: | MEM-171 |
| Clonality: | Monoclonal |
| Immunogen: | Tissue / cell preparation (Human granulocytes). |
| Epitope: | MEM 171 recognizes an epitope in the D2 domain of human CD50 (ICAM 3). |
| Specificity: | The antibody MEM-171 recognizes an epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 mg Liquid |
| Uses: | FACS: Use at an assay dependant concentration. IP: Use at an assay dependant concentration. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane; Type I membrane protein. |
| Background: | All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA1 protein. ICAM3 is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Upon stimulation by a physiological stimulus it becomes rapidly and transiently phosphorylated on serine residues. N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS. pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | FACS, IP |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CD50 antibody, anti-CD50 antigen antibody, anti-CDW 50 antibody, anti-CDW50 antibody, anti-ICAM 3 antibody, anti-ICAM R antibody, anti-ICAMR antibody, anti-Intercellular adhesion molecule 3 antibody |
| ProteinTarget: | CD50 |
| PackageSize: | 0.1 mg |
| GeneralRef: | This product has been used in:Kishimoto T. et al. (Eds.) Leucocyte typing VI. Garland Publishing Inc. : (1997). |
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