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| Catalog Code: | NB120-10442 |
| Product Name: | Cystatin A Antibody |
| Product Description: | Mouse Monoclonal anti-Cystatin A (WR-23/2/3/3) |
| Clone: | WR-23/2/3/3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | human cystatin A |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.5 ml |
| Uses: | IHC-P: Use at a dilution of 1/4000. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.WB: Use at an assay dependent dilution. Detects a band of approximately 11-13 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Cystatins are endogenous inhibitors of lysosomal proteases that form a superfamily that is classified into three families (families 1,2 and 3) according to the homology of the amino acid sequences. Cystatin A (also termed acid cysteine proteinase inhibitor, ACPI, stefin A, and epidermal SH- proteinase inhibitor) belongs to family 1 of the cystatin superfamily of proteins. These proteins are natural inhibitors of cysteine proteinases like cathepsin B, H, L, and S. Cystatin A, a 98 amino acid protein (11-13 kDa), is detected in normal squamous epithelium, follicular dendritic cells in lymphoid tissues, thymic epithelial cells (in Hassall's corpuscles and in medulla), liver cells, granulocytes and basal epithelial cells in the prostate. Cystatin A is thought to be a tumor suppressor, since an inverse correlation seems to exist between the level of cystatin A and tumor progression, in several malignancies. Also, Cystatin A has been implicated in aging of tissues, Alzheimer disease, viral infections and inflammatory processes. |
| Storage: | Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | Preservative: 15mM Sodium Azide |
| Application Summary: | Immunohistochemistry-Paraffin, Western Blot, |
| Species Summary: | Hu |
| Alternate Names: | anti-CSTA antibody, anti-CSTA protein antibody, anti-Cystatin A antibody, anti-Cystatin AS antibody, anti-CystatinA antibody, anti-Stefin A antibody, anti-Stefin A1 antibody, anti-StefinA antibody, anti-STF 1 antibody, anti-STF1 antibody, anti-STFA antibody |
| Package Size: | 0.05 ml |
| General References: | General / background references:Kuopio T et al. Cysteine proteinase inhibitor cystatin A in breast cancer. Cancer Res 58:432-6 (1998). Calkins CC & Sloane BF Mammalian cysteine protease inhibitors: biochemical properties and possible roles in tumor progression. Biol Chem Hoppe Seyler 376:71-80 (1995). Weber E et al. Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth. J Cancer Res Clin Oncol 120:564-7 (1994). |
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