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| Catalog Code: | NB120-10405 |
| Product Name: | CXCR5 Antibody |
| Product Description: | Mouse Monoclonal anti-CXCR5 (51505.111) |
| Clone: | 51505.111 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Human CXCR5 (BLR1) transfected NSO mouse myeloma cells. |
| Specificity: | Human CXCR5 reacts with CXCR5 (BLR1) transfected cells but not with the parent cell line by flow cytometry. The antibody shows no cross-reactivity with human CXCR2, CXCR3 and CXCR4. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | FACS: Use 10-25 mg/ ml for 10 micro litres (10 to the 5th)cells (determined using human peripheral blood mononuclear cells expressing CXCR5.) Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Integral membrane protein |
| Background: | This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein- coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse conterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist. |
| Storage: | Store at -20 degrees long term. |
| Purity: | protein G purified |
| Isotype: | IgG2b |
| Host Name: | Mouse |
| Buffer: | PBS |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu, |
| Alternate Names: | anti-BLR1 antibody, anti-Burkitt Lymphoma Receptor 1 GTP Binding Protein antibody, anti-C X C chemokine receptor type 5 antibody, anti-CD 185 antibody, anti-D185 antibody, anti-CD185 antigen antibody, anti-Chemokine C X C motif receptor 5 antibody, anti-Chemokine CXC motif receptor 5 antibody, anti-Chemokine receptor 5 antibody, anti-CXC chemokine receptor type 5 antibody, anti-CXC R5 antibody, anti-CXCR 5 antibody, anti-MDR15 antibody, anti-MGC117347 antibody, anti-Monocyte Derived Receptor 15 antibody |
| Package Size: | 0.1 mg |
| Preservative: | No preservatives |
| Notes Main: | Endotoxin level is < 10 ng per mg antibody |
| General References: | Wells TN et al. Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol Sci 19:376-80 (1998). <PUBMED:9786026> Gunn MD et al. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 391:799-803 (1998). <PUBMED:9486651> Forster R et al. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037-47 (1996). <PUBMED:8978608> |
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more information: | company product webpage |