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| Catalog Code: | NB120-10398 |
| Product Name: | CCR6 Antibody |
| Product Description: | Mouse Monoclonal anti-CCR6 (53103.111) |
| Clone: | 53103.111 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Human CCR6 transfected NSO mouse myeloma cells. |
| Specificity: | Human CCR6 reacts with CCR6 transfected cells and not with the parent cell line by flow cytometry. The antibody shows no cross-reactivity with CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4 and STRL33 transfected cells. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse IgG. |
| Uses: | FACS: Use 5ug for 10<sup>5</sup> cells. (Determined using human CCR-6 on peripheral blood mononuclear cells (PBMC)).Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Integral membrane protein |
| Background: | CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. It is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP 3 alpha). This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells. |
| Purity: | protein G purified |
| Isotype: | IgG2b |
| Host Name: | Mouse |
| Buffer: | Preservative: NoneConstituents: PBSEndotoxin level is < 10 ng per mg antibody as determined by the L |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | anti-BN 1 antibody, anti-BN1 antibody, anti-C C chemokine receptor type 6 antibody, anti-C C CKR 6 antibody, anti-CC chemokine receptor type 6 antibody, anti-CC CKR 6 antibody, anti-CC R6 antibody, anti-CCCKR6 antibody, anti-CCR 6 antibody, anti-CD 196 antibody, anti-CD196 antibody, anti-CD196 antigen antibody, anti-Chemokine (C C motif) receptor 6 antibody, anti-Chemokine (C C) receptor 6 antibody, anti-Chemokine (CC motif) receptor 6 antibody, anti-Chemokine (CC) receptor 6 antibody, anti-Chemokine receptor 6 antibody, anti-Chemokine receptor like 3 antibody, anti-CKR 6 antibody, anti-CKR L3 antibody, anti-CKR6 antibody, anti-CKRL3 antibody, anti-CMKBR 6 antibody, anti-CMKBR6 antibody, anti-DCR 2 antibody, anti-DCR2 antibody, anti-DRY 6 antibody, anti-DRY6 antibody, anti-G protein coupled receptor 29 antibody, anti-GPR 29 antibody, anti-GPR CY4 antibody, anti-GPR29 antibody, anti-GPRCY 4 antibody, anti-GPRCY4 antibody, anti-LARC receptor antibody, anti-Seven transmembrane receptor lymphocyte 22 antibody, anti-STRL 22 antibody, anti-STRL22 antibody |
| Package Size: | 0.1 mg |
| General References: | General / background references:Wells TN et al. Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol Sci 19:376-80 (1998). Greaves DR et al. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med 186:837-44 (1997). Baba M et al. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem 272:14893-8 (1997). |
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