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| Catalog Code: | NB120-10396 |
| Product Name: | CCR2 Antibody |
| Product Description: | Mouse Monoclonal anti-CCR2 (48607.121) |
| Clone: | 48607.121 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Human CCR2 transfected NSO mouse myeloma cells. |
| Specificity: | Monoclonal Anti-Human CCR2 reacts with CCR2 transfected cells and not the parent cell line by flow cytometry. The antibody shows no cross-reactivity with CCR5 transfected cells. The antibody reacts with CCR-2 transfectant cells and not the parent cell line. It shows no cross-reactivity with CCR-5 transfectant cells. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse IgG. |
| Uses: | FACS: Use 5ug for 10<sup>5</sup> human CCR-2 transfected cells..Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Background: | CCR2, or C C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus. |
| Purity: | protein G purified |
| Isotype: | IgG2b |
| Host Name: | Mouse |
| Buffer: | Preservative: None Constituents: PBS Endotoxin level is < 10 ng per mg antibody as determined b |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | anti-CC-CKR-2 antibody, anti-CCR2A antibody, anti-CCR2B antibody, anti-CKR2 antibody, anti-CKR2A antibody, anti-CKR2B antibody, anti-CMKBR2 antibody, anti-MCP-1-R antibody |
| Package Size: | 0.1 mg |
| General References: | General / background references:Wells TN et al. Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol Sci 19:376-80 (1998). Charo IF et al. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A 91:2752-6 (1994). |
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