| CatalogCode: | NB120-10390 |
| ProductName: | MCP1 Antibody |
| Product Description: | Mouse Monoclonal anti-MCP1 (24822.11) |
| Clone: | 24822.11 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant human MCP-1 (rhMCP-1), expressed in E. coli. |
| Specificity: | The antibody will neutralize the biological activity of recombinant human MCP-1.This antibody does not exhibit cross-reactivity with recombinant human RANTES, recombinant human MIP-1á, or recombinant mouse MIP-1á.. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Mouse IgG. |
| Uses: | Neut: Use at a concentration of 0.1 ug/ml. Human MCP1 is tested for its ability to neutralize the chemoattractant activity of rhMCP1 for human monocytes. The ND50 of the antibody is defined as the concentration of antibody resulting in a one-half maximal inhibition of bioactivity of rhMCP1 that was present at a concentration just high enough to elicit a maximum response. In this bioassay, rhMCP1 was preincubated with various dilutions of the antibody for 1 hour at 37 |
| Localization: | Secreted |
| Background: | This chemotactic factor attracts monocytes and basophils but not neutrophils or eosinophils and augments monocyte anti-tumor activity. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. It may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Preservative: None Constituents: PBS |
| ListPrice: | 285 |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CCL 2 antibody, anti-CCL2 antibody, anti-Chemokine C C motif ligand 2 antibody, anti-Chemokine CC Motif Ligand 2 antibody, anti-GDCF 2 antibody, anti-GDCF 2 HC11 antibody, anti-GDCF2 antibody, anti-HC11 antibody, anti-HSMCR30 antibody, anti-MCAF antibody, anti-MCP 1 antibody, anti-MGC9434 antibody, anti-Monocyte chemoattractant protein 1 antibody, anti-Monocyte chemotactic and activating factor antibody, anti-Monocyte chemotactic protein 1 antibody, anti-Monocyte secretory protein JE antibody, anti-SCYA2 antibody, anti-Small inducible cytokine A2 antibody, anti-Small inducible cytokine subfamily A Cys Cys member 2 antibody, anti-SMC CF antibody, anti-SMCCF antibody |
| ProteinTarget: | MCP1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | General / background references:Miller MD & Krangel MS Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit Rev Immunol 12:17-46 (1992). Mukaida N et al. Properties of pro-inflammatory cell type-specific leukocyte chemotactic cytokines, interleukin 8 (IL-8) and monocyte chemotactic and activating factor (MCAF). Microbiol Immunol 36:773-89 (1992). Matsushima K et al. Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J Exp Med 169:1485-90 (1989). Furutani Y et al. Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF). Biochem Biophys Res Commun 159:249-55 (1989). |
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