| CatalogCode: | NB120-10349 |
| ProductName: | TIE2 Antibody |
| Product Description: | Goat Polyclonal anti-TIE2 |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant full-length protein (Human). |
| Specificity: | By immunoblotting, this antibody exhibits no cross-reactivity with recombinant human TIE1. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.025 mg |
| Uses: | ELISA: Use at a concentration of 0.5 - 1.0 ug/ml. Neut: Use at an assay dependent concentration. WB: Use at a concentration of 0.1 - 0.2 ug/ml. Detects a band of approximately 165 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Single pass type I membrane protein. |
| Background: | TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide-linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Due to glycosylation, the protein migrates to approximately 160 kDa in SDS-PAGE under reducing conditions. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene-targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation. The receptor tyrosine kinase TIE also plays a role in the survival and integrity of the endothelium. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Preservative: None Constituents: PBS |
| ListPrice: | 285 |
| AppSummary: | ELISA, WB, FC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Angiopoietin 1 receptor antibody, anti-CD202b antibody, anti-CD202b antigen antibody, anti-Endothelium specific receptor tyrosine kinase 2 antibody, anti-hTIE 2 antibody, anti-hTIE2 antibody, anti-p140 TEK antibody, anti-TEK antibody, anti-TEK tyrosine kinase endothelial antibody, anti-TIE 2 antibody, anti-Tunica interna endothelial cell kinase antibody, anti-Tyrosine protein kinase receptor TEK antibody, anti-Tyrosine protein kinase receptor TIE 2 antibody, anti-Venous malformations multiple cutaneous and mucosal antibody, anti-VMCM 1 antibody, anti-VMCM antibody, anti-VMCM1 antibody |
| ProteinTarget: | TIE2 |
| PackageSize: | 0.025 mg |
| GeneralRef: | Sato TN et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376:70-4 (1995). Sato TN et al. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc Natl Acad Sci U S A 90:9355-8 (1993). Partanen J et al. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol Cell Biol 12:1698-707 (1992). |
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