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| Catalog Code: | NB120-10252 |
| Product Name: | Transferrin Receptor Antibody |
| Product Description: | Mouse Monoclonal anti-Transferrin Receptor (2B6) |
| Clone: | 2B6 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant full length protein (Human). |
| Specificity: | This antibody reacts with human soluble transferrin receptor. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.2 mg protein A purified Mouse IgG. |
| Uses: | ELISA: Use at an assay dependent dilution. Recommended pair antibody: NB120-10252 (coating) with NB120-10249 (detection).ab 10253 (detection) with NB120-10252 (coating). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane and Secreted |
| Background: | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. |
| Storage: | + 4 °C |
| Purity: | protein A purified |
| Isotype: | IgG2a |
| Host Name: | Mouse |
| Buffer: | PBS. pH 7.4 |
| Application Summary: | ELISA |
| Species Summary: | Hu, |
| Alternate Names: | anti-CD 71 antibody, anti-CD71 antibody, anti-p90 antibody, anti-T9 antibody, anti-TFR 1 antibody, anti-TFR1 antibody, anti-TFRC antibody, anti-Transferrin Receptor Protein 1 antibody, anti-TRFR antibody |
| Package Size: | 0.2 mg |
| Preservative: | 0.1% Sodium Azide |
| Notes Main: | This antibody can be used in a sandwich ELISA (coating - conjugate) with the following clone: 5B11 - 2B6 For Sandwich ELISA pair this antibody with: NB110-8470 |
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