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| Catalog Code: | NB120-10176 |
| Product Name: | Plasminogen Antibody |
| Product Description: | Mouse Monoclonal anti-Plasminogen (8E7) |
| Clone: | 8E7 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Full length native protein (purified) (Human). |
| Specificity: | Reacts with human plasminogen and plasmin molecules. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.2 mg IgG purified Mouse IgG. |
| Uses: | AP: Use at an assay dependent dilution. ELISA: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. Antigen retrieval is not essential but may optimise staining.Can be used in ELISA with NB120-10177 and NB120-10173 (coating).Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Secreted |
| Background: | Plasminogen is a plasma protein synthesised mostly in the liver. Plasma concentration is usually in the range of 70 to 200mg/l. Plasminogen is activated by tissue plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Angiostatin, an internal fragment of plasminogen, is a potent inhibitor of angiogenesis, which selectively inhibits endothelial cell proliferation. Angiostatin potently inhibits tumor growth and can maintain metastatic and primary tumors in a dormant state. It is defined by a balance of proliferation and apoptosis of the tumor cells and is composed of plasminogen first four cringle structures. This molecule is generated by proteolytic cleavage of plasminogen. |
| Storage: | + 4 degrees Celsius |
| Purity: | IgG purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS. pH 7.4 |
| Application Summary: | immunoprecipitation, ELISA, immunohistochemistry-P |
| Species Summary: | Hu, |
| Alternate Names: | anti-Angiostatin antibody, anti-Microplasmin antibody, anti-PLG antibody |
| Package Size: | 0.2 mg |
| Preservative: | 0.1% Sodium Azide |
| Notes Main: | This antibody can be used in a sandwich ELISA (coating - conjugate) with the following clone: 8F11 - 8E7 For Sandwich ELISA pair this antibody with: NB120-10177 |
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