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| Catalog Code: | NB120-10066 |
| Product Name: | Fibrinogen Antibody |
| Product Description: | Mouse Monoclonal anti-Fibrinogen (1F3) |
| Clone: | 1F3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Fibrin degradation products. |
| Specificity: | Fibrinogen, Fibrin degradation products. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.2 mg protein A purified Mouse IgG. |
| Uses: | ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Can be paired for ELISA with <ab10067>Mouse monoclonal [27C8] to Fibrinogen</ab> as detection and <ab10068>Mouse monoclonal [40F11] to Fibrinogen</ab> as capture. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Secreted |
| Background: | Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases. |
| Storage: | + 4 °C |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-FGA antibody, anti-FGA protein antibody, anti-FGB antibody, anti-FGG antibody,anti-Fib2 antibody , anti-Fibrinogen A alpha polypeptide chain antibody, anti-Fibrinogen alpha chain antibody, anti-Fibrinogen beta chain antibody, anti-Fibrinogen gamma chain antibody, anti-MGC104327 antibody, anti-MGC119422 antibody, anti-MGC119423 antibody, anti-MGC119425 antibody, anti-MGC120405 antibody |
| Package Size: | 0.2 mg |
| Preservative: | 0.1% Sodium Azide |
| Notes Main: | This antibody can be used in a sandwich ELISA (coating - conjugate) with the following clone: 1F3 - 27C8 or 40F11 - 1F3 or 1F7 (anti-fibrinopeptide A) - 1F3 (anti-fibrinogen) For Sandwich ELISA pair this antibody with: NB200-420, NB120-10068, or NB120-14790 (Fibrinopeptide A) |
| General References: | Lowe G et al. Blood rheology, cardiovascular risk factors, and cardiovascular disease: the West of Scotland Coronary Prevention Study. Thromb Haemost 84:553-8 (2000). Danesh J et al. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 279:1477-82 (1998). |
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