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| Catalog Code: | NB110-93591SS |
| Product Type: | Primary Antibody |
| Product Name: | TLR3 Antibody |
| List Price: | 125 |
| Clonality: | Polyclonal |
| Gene ID: | 7098 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-TLR3, Sample Size |
| Cross Reactivity: | Human. |
| Species Summary: | Hu(+), |
| Background: | TLR3 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. |
| Alternate Names: | anti-Toll-like receptor 3 antibody, anti-TLR-3 antibody, anti-CD283 antigen antibody |
| Immunogen: | Synthetic peptide made to a C-terminal portion of the human protein (within residues 800-904). [Swiss-Prot# O15455] |
| Localization: | Cell membrane; Single-pass type I membrane protein |
| Purity: | peptide affinity purified |
| Buffer: | Tris-citrate/phosphate, pH 7-8 |
| Preservative: | 0.1% sodium azide |
| Packaging: | 0.025 ml peptide affinity purified Rabbit antisera. |
| Package Size: | 0.025 ml |
| Concentration: | 1.0 mg/ml |
| Uses: | This antibody is useful for Western blot, where a band is seen ~105 kDa. |
| Application Summary: | Western Blot 2.0 mg/ml, |
| Storage: | Store at 4C. |
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