| request information: |
|
| Catalog Code: | NB110-8557 |
| Product Name: | LTBR Antibody |
| Product Description: | Goat Polyclonal anti-LTBR |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Concentration: | 0.1 mg/ml |
| Immunogen: | Recombinant human lymphotoxin betaR extracellular domain, expressed in mouse NSO cells. |
| Packaging: | 0.05 mg Immunogen affinity purified Goat antisera. |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | Tumor necrosis factor-beta (TNF-beta), also known as lymphotoxin (LT or LT-a) and cytotoxic factor, is a 25 kDa glycoprotein that is tightly regulated by lymphocytes. TNF-beta and TNF-alpha share a 28% amino acid sequence identity, and as soluble forms, both can exist in solution as homotrimers, activate the same TNF receptors (TNFR1 and TNFR2) and elicit many of the same bioactivities. Unlike TNF-alpha, TNF-beta can also form heterotrimers with one or two molecules of the related membrane-bound lymphotoxin-beta (LT-beta). Reportedly, LT-alpha1/beta2, the predominant heterotrimer, binds and activates only the LT-beta receptor, LT-betaR. The other heterotrimer, LT-alpha2/beta1 binds and activates TNFR1 and TNFR2 but not LT-betaR. TNF-beta is expressed in activated T, B and NK cells and in certain transformed cells. Genes for TNF-beta, LT-beta and TNF-alpha are tightly linked near each other within the MHC. TNF-beta appears to play many of the same biological roles as TNF-alpha, but the membrane-bound form with LT-beta is critical for normal lymphoid organ development. Genetic polymorphisms in TNF-alpha and TNF-beta have been linked to certain pathological conditions, including myasthenia gravis. At the amino acid level, human and mouse TNF-beta are 74% homologous and human and mouse LT-beta are 80% homologous. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | PBS |
| Application Summary: | ELISA 0.5-1.0 ug/ml to detect a limit of 0.16 ng/well of recombinant human lymphotoxin beta receptor, Western Blot 0.1 - .02 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-Lymphotoxin beta receptor antibody; anti-TNFR2Rp antibody; anti-CD18 antibody; anti-TNFCR antibody |
| Package Size: | 0.05 mg |
| Notes Main: | Endotoxin level is < 10 ng per mg antibody as determined by the LAL method. |
| General References: | 1. Turetskaya, R.L., Polymorphism of the tumor necrosis factor genes: association with disease. Mol. Biol., 33, 355-359 (1999). 2. Ware, C., et al., Tumor necrosis factor-related ligands and receptors, in The Cytokine Handbook, 3rd Edition, Thomson, A.W., (ed.), Academic Press (San Diego, CA: 1998), pp. 549-592. 3. Zhai, Y.F., et al., Light, a novel ligand for lymphotoxin b receptor and tr2/hvem induces apoptosis and suppresses in vivo tumor formation via gene transfer. J. Clin. Invest., 102, 1142-1151 (1998). 4. Rennert, P.D., et al., Lymph node genesis is induced by signaling through the lymphotoxin b receptor. Immunity, 9, 71-79 (1998). 5. Browning, J.L., et al., Characterization of lymphotoxin-a-b complexes on the surface of mouse lymphocytes. J. Immunol., 159, 3288-3298 (1997). |
order or
more information: | company product webpage |
|
|