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| Catalog Code: | NB110-85521 |
| Product Name: | Cenexin-1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Cenexin-1 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Concentration: | 1.1 mg/ml |
| Immunogen: | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues near the carboxy terminus. |
| Specificity: | This antibody is specific for human Cenexin-1 protein. A BLAST analysis was used to suggest cross-reactivity with Cenexin-1 from human, chimpanzee and macaque based on 100% homology with the immunizing sequence. |
| Cross Reactivity: | This antibody is reactive to Human. Expected reactivity to Chimpanzee and Macaque due to sequence homology. |
| Packaging: | 0.1 mg Affinity purified Rabbit antisera. |
| Uses: | This antibody has been tested for use in ELISA and western blotting. Expect a band approximately 93 kDa in size corresponding to Cenexin-1. |
| Background: | Cenexin-1, also known as ODF2 and outer dense fiber of sperm tails 2, are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. Cenexin-1 is one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of the cenexin gene; however, not all isoforms and variants have been fully described. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Host Name: | Rabbit |
| Buffer: | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
| Application Summary: | ELISA 1:2000-1:10000, immunohistochemistry User Optimized, Western Blot 1:200-1:2000, |
| Species Summary: | Hu, Mk, |
| Alternate Names: | anti-sperm tail structural protein antibody, anti-Cenexin 1 antibody, anti-Cenexin1 variant 1 antibody, anti-ODF2 antibody, anti-outer dense fiber of sperm tails antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.01% Sodium Azide |
| General References: | 1. Soung,N.K., Kang,Y.H., Kim,K., et al. Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol. Cell. Biol. 2006;26 (22), 8316-8335. 2. Kierszenbaum,A.L. Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells. Mol. Reprod. Dev. 2002;61 (1), 1-2. 3. Petersen,C., Fuzesi,L. and Hoyer-Fender,S. Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa. Mol. Hum. Reprod. 1999;5 (7), 627-635. 4. Hoyer-Fender,S., Petersen,C., Brohmann,H., et al. Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail. Mol. Reprod. Dev. 1998;51 (2), 167-175. 5. Shao,X., Murthy,S., Demetrick,D.J. and van der Hoorn,F.A. Human outer dense fiber gene, ODF2, localizes to chromosome 9q34. Cytogenet. Cell Genet. 1998;83 (3-4), 221-223. |
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