| CatalogCode: | NB110-8468 |
| ProductName: | Transferrin Receptor Antibody |
| Product Description: | Mouse Monoclonal anti-Transferrin Receptor (23D10) |
| Clone: | 23D10 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant full length protein (Human). |
| Specificity: | This antibody reacts with human soluble transferrin receptor. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 mg |
| Uses: | ELISA: Use at an assay dependent dilution. Recommended pair antibody: ab10251 (detection) with ab10254 (coating).Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane and Secreted |
| Background: | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. |
| Isotype: | IgG2b |
| Host_Name: | Mouse |
| Buffer: | PBS. pH 7.4 |
| ListPrice: | 295 |
| AppSummary: | ELISA |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CD 71 antibody, anti-CD71 antibody, anti-p90 antibody, anti-T9 antibody, anti-TFR 1 antibody, anti-TFR1 antibody, anti-TFRC antibody, anti-Transferrin Receptor Protein 1 antibody, anti-TRFR antibody |
| ProteinTarget: | Transferrin Receptor |
| PackageSize: | 0.1 mg |
| NotesMain: | Concentration varies from lot to lot and can be provided on request. |