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| Catalog Code: | NB110-8342 |
| Product Name: | Human IgA Antibody |
| Product Description: | Mouse Monoclonal anti-Human IgA (3B7) |
| Clone: | 3B7 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | IgA from human colostrum. |
| Specificity: | IgA Fc region |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 1 mg protein G purified Mouse ascites. |
| Uses: | ELISA: Use at an assay dependent dilution. ID: Use at an assay dependent dilution. Can be used in passive haemagglutination. For detection of total IgA (pan IgA) ab7400 can be used as the coating agent with either ab7383 or ab7402 used as the conjugate Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Secreted |
| Background: | Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. |
| Storage: | + 4 °C |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS. pH 7.4 |
| Application Summary: | ELISA, RID |
| Species Summary: | Hu |
| Alternate Names: | anti-GAMMA-A-GLOBULIN antibody |
| Package Size: | 1 mg |
| Preservative: | 0.1% Sodium Azide |
| Notes Main: | This antibody can be used in a sandwich ELISA (coating - conjugate) with the following clone: 3B7 - 1H9 For Sandwich ELISA pair this antibody with: NB110-8340 |
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