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| Catalog Code: | NB110-81760 |
| Product Name: | PUMA Antibody |
| Product Description: | Rabbit Polyclonal anti-PUMA |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Gene ID: | 27133 |
| Concentration: | 1.0 mg/ml |
| Immunogen: | Synthetic peptide made to an N-terminal portion of the human protein (within residues 1-100). [NCBI Sequence NP_001120712] |
| Specificity: | This antibody is specific for isoform 1 of PUMA. |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot, where a band is seen ~24 kDa. |
| Localization: | Mitochondrial |
| Background: | A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. |
| Storage: | Store at 4C. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate, pH 7-8 |
| Application Summary: | Western Blot 1.0 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-p53 Upregulated Modulator of Apoptosis antibody; anti-Bcl-2 binding component 3 antibody; anti-JFY-1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.1% sodium azide |
| General References: | 1. Nakano K., and Vousden K.H. Mol Cell, 7(3):683-94 (2001). 2. Yu, J, et al. PNAS, 100(4):1931-1936 (2003). 3. Yamaguchi, H. and Wang, HG. JBC 279(44):45495-45502 (2004). |
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