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| Catalog Code: | NB110-79876 |
| Product Name: | Kappa Opioid Receptor Antibody |
| Product Description: | Rabbit Polyclonal anti-Kappa Opioid Receptor |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide comprising residues 366-380 of the human KOR-1 protein. Sequence identity is 66% in mouse and rat. |
| Epitope: | DPAYLRDIDGMNLPV |
| Cross Reactivity: | Human and rat. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody may be used for western analysis. |
| Background: | G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that activate intracellular signaling cascades and undergo endocytosis, recycling, or degradation upon stimulation. The (mu), delta and kappa opioid receptors are GPCRs of the nervous system, which control pain, stress, and addictive behaviors. The kappa opioid receptor (KOR-1) plays a role in arousal and regulation of autonomic and neuroendocrine functions and is the receptor for dynorphins. KOR-1 inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-OPRK1 antibody, anti-Opioid Receptor, Kappa-1 antibody, anti-KOR-1 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% sodium azide |
| General References: | 1. Simonin, F., Gaveriaux-Ruff, C., Befort, K., Matthes, H., Lannes, B., Micheletti, G., Mattei, M.G., Charron, G., Bloch, B. and Kieffer, B. kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 92 (15), 7006-7010 (1995). 2. Bruchas, M.R., Yang, T., Schreiber, S., Defino, M., Kwan, S.C., Li, S. and Chavkin, C. Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. J. Biol. Chem. 282 (41), 29803-29811 (2007). |
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