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| Catalog Code: | NB110-75106 |
| Product Name: | ubiquitin-binding protein p62 Antibody |
| Product Description: | Rabbit Polyclonal anti-ubiquitin-binding protein p62 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | ORCA_HUMAN |
| Immunogen: | A synthetic peptide as a part of sequestosome-1 (ubiquitin-binding protein p62, p60, EBIAP) conjugated to immunogenic carrier protein has been used as the immunogen. |
| Specificity: | Appears to be specific for sequestosome-1. |
| Cross Reactivity: | Human. Other species not yet tested. |
| Packaging: | 0.15 ml of Whole antisera antibody |
| Uses: | IHC (both on frozen and paraffin embedded tissues), WB 1 : 200 to 1 : 5000. The optimal dilution should be determined by the end user. |
| Background: | FUNCTION: Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.; SUBCELLULAR LOCATION: Cytoplasm. Late endosome. Nucleus. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.; TISSUE SPECIFICITY: Ubiquitously expressed. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry , Western Blot 1:200 to 1:5000 |
| Species Summary: | Hu |
| Alternate Names: | anti-Sequestosome 1 antibody, anti-phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody, anti-ubiquitin-binding protein p62 antibody, anti-EBI3-associated protein of 60 kDa antibody, anti-p60 antibody, anti-EBIAP antibody, anti-SQSTM1 antibody, anti-A170 antibody, anti-OSIL antibody, anti-PDB3 antibody, anti-ZIP3 antibody, anti-p62B antibody |
| Package Size: | 0.15 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 150 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Devergne O, et al. J. Virol. 70:1143-1153(1996). 2. Joung I, et al. Proc. Natl. Acad. Sci. U.S.A. 93:5991-5995(1996). 3. Stumptner C, et al. Am. J. Pathol. 154:1701-1710(1999). 4. Vadlamudi R.K, et al. J. Biol. Chem. 271:20235-20237(1996). 5. Hocking L.J, et al. J. Bone Miner. Res. 19:1122-1127(2004). 6. Good D.A, et al. Bone 35:277-282(2004). 7. Hocking L.J, et al. Hum. Mol. Genet. 11:2735-2739(2002). 8. Ciani B, et al. J. Biol. Chem. 278:37409-37412(2003). 9. Nousiainen M, et al. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). 10. Olsen J.V, et al. Cell 127:635-648(2006). |
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