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| Catalog Code: | NB110-75105 |
| Product Name: | FGF2 Antibody |
| Product Description: | Sheep Polyclonal anti-FGF2 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | FGF_HUMAN ; FGF_OPOSSUM ; FGF_MOUSE ; FGF_RAT ; FGF_GUINEA PIG |
| Immunogen: | A synthetic peptide as a part of opossum, chimpanzee, mouse, rat, guinea pig and human basic FGF conjugated to immunogenic carrier protein was used as the immunogen. |
| Specificity: | Appears to be specific for FGF2. |
| Cross Reactivity: | Opossum, mouse, guinea pig, rat, human |
| Packaging: | 0.15 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user. |
| Background: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Sheep |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry , Western Blot 1:300 to 1:3000 |
| Species Summary: | Mu, Gp, Rt, Hu |
| Alternate Names: | anti-BFGF antibody, anti-FGFB antibody, anti-HBGF-2 antibody, anti-prostatropin antibody |
| Package Size: | 0.15 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 150 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Alexander S, et al. Arthritis Rheum. 56 (11), 3715-3725(2007). 2. Neuzil J, et al. FEBS Lett. 581 (24), 4611-4615(2007). 3. Arkudas A, et al. Mol. Med. 13 (9-10), 480-487(2007). 4. Arnaud E, Mol. Cell. Biol. 19 (1), 505-514(1999). 5. Watson R, et al. Biochem. Biophys. Res. Commun. 187 (3), 1227-1231(1992). 6. Ago H, et al. J. Biochem. 110 (3), 360-363(1991). 7. Eriksson A.E, et al. Proc. Natl. Acad. Sci. U.S.A. 88 (8), 3441-3445(1991). 8. Zhu X, et al. Science 251 (4989), 90-93(1991). 9. Prats H, et al. Proc. Natl. Acad. Sci. U.S.A. 86 (6), 1836-1840(1989). |
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