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| Catalog Code: | NB110-75102 |
| Product Name: | ARC Antibody |
| Product Description: | Sheep Polyclonal anti-ARC |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | Arg3.1/ARC_HUMAN ; Arg3.1/ARC_MOUSE ; Arg3.1/ARC_RAT |
| Immunogen: | Synthetic peptides (a pentamer) as parts of human, mouse and rat Arg3.1 (ARC) was used as the immunogen. |
| Specificity: | Appears to be specific for Arg3.1/ARC. |
| Cross Reactivity: | Human, mouse and rat. Other species not yet tested. |
| Packaging: | 0.5 mg of IgG purified antibody |
| Uses: | IHC, WB. This is one of the best (if not the one) antibodies against Arg3.1 available with an extremely hight titre with no apparent back ground staining, it is highly recommended. Use at a concentration of 1-10 µg/ml. The optimal workiing concentration should be determined by the end user. |
| Background: | FUNCTION: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Sheep |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-Activity-regulated cytoskeleton-associated protein antibody, anti-Activity-regulated gene 3.1 protein homolog antibody, anti-KIAA0278 antibody, anti-Arg3.1/ARC antibody |
| Package Size: | 0.5 mg |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Tan J, et al. Neuroscience. 16;145(2):715-26(2007). 2. Link,W, et al. Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5734-5738 (1995). 3. Shepherd J.D, et al. Neuron 52:475-484(2006). 4. Rial Verde E.M, et al. Neuron 52:461-474(2006). 5. Chowdhury S, et al. Neuron 52:445-459(2006). |
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more information: | company product webpage |