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| Catalog Code: | NB110-75007 |
| Product Name: | TRPC7 Antibody |
| Product Description: | Sheep Polyclonal anti-TRPC7 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | TRPC7_HUMAN ; TRPC7_MOUSE |
| Immunogen: | A synthetic peptide as a part of human and mouse TRPC7, conjugated to immunogenic carrier protein was used as the immunogen. |
| Specificity: | Appears to be specific for TRPC7. |
| Cross Reactivity: | Human and mouse. Other species not yet tested. |
| Packaging: | 0.1 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. |
| Background: | FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Sheep |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry , Western Blot 1:300 to 1:4000 |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-Short transient receptor potential channel 7 antibody, anti-TrpC7 antibody, anti-mTRP7 antibody, anti-Trp7 antibody, anti-Trrp8 antibody, anti-Trpc7 antibody, anti-TrpC7 antibody, anti-TRP7 protein antibody, anti-TRP7 antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Numaga T, et al. Handb Exp Pharmacol 179, 143-151 (2007). 2. Beck B, J, et al. Invest. Dermatol. 126 (9), 1982-1993 (2006). 3. Clapham D.E, et al. Pharmacol. Rev. 57 (4), 427-450 (2005). 4. Lievremont J.P, et al. J. Biol. Chem. 280 (42), 35346-35351 (2005). 5. Zagranichnaya T.K, et al. J. Biol. Chem. 280 (33), 29559-29569 (2005). 6. Lussier M.P, et al. J. Biol. Chem. 280 (19), 19393-19400 (2005). 7. Lievremont J.P, et al. Am. J. Physiol., Cell Physiol. 287 (6), C1709-C1716 (2004). |
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