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| Catalog Code: | NB110-74998 |
| Product Name: | TRPM2 Antibody |
| Product Description: | Sheep Polyclonal anti-TRPM2 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | TRPM2_HUMAN |
| Immunogen: | A synthetic peptide as a part of human TRPM2 conjugated to immunogenic carrier protein was used as the immunogen. |
| Specificity: | Appears to be specific for TRPM2. |
| Cross Reactivity: | Human. Other species not yet tested. |
| Packaging: | 0.1 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. |
| Background: | The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.; FUNCTION: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress.; CATALYTIC ACTIVITY: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Sheep |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry , Western Blot 1:300 to 1:4000 |
| Species Summary: | Hu |
| Alternate Names: | anti-Transient receptor potential cation channel subfamily M member 2 antibody, anti-long transient receptor potential channel 2 antibody, anti-LTrpC2 antibody, anti-LTrpC-2 antibody, anti-transient receptor potential channel 7 antibody, anti-TrpC7 antibody, anti-estrogen-responsive element-associated gene 1 protein antibody, anti-EREG1 antibody, anti-KNP3 antibody, anti-LTRPC2 antibody, anti-TRPC7 antibody, anti-KNP3 antibody, anti-NUDT9H antibody, anti-NUDT9L1 antibody, anti-MGC133383 antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Nagamine K, et al. Genomics 54:124-131(1998). 2. Wehage E, et al. J. Biol. Chem. 277:23150-23156(2002). 3. Zhang W, et al. J. Biol. Chem. 278:16222-16229(2003). 4. Hattori M, et al. Nature 405:311-319(2000). 5. Perraud A.-L, et al. Nature 411:595-599(2001). 6. Sano Y, et al. Science 293:1327-1330(2001). 7. Hara Y, et al. Mol. Cell 9:163-173(2002). |
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