| request information: |
|
| Catalog Code: | NB110-74993 |
| Product Name: | TRPC4 Antibody |
| Product Description: | Sheep Polyclonal anti-TRPC4 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | TRPC4_RAT ; TRPC4_HUMAN ; TRPC4_MOUSE ; See also the immunogen. |
| Immunogen: | A synthetic peptide as a part of rat (and isoforms: alpha, beta, beta-2, theta, iota, kappa) mouse, human (and isoforms: CRA-a, b, c, g, f) TRPC4 (TRP4) conjugated to immunogenic carrier protein was used as the immunogen. The antigen is homologous in may other species as well. |
| Specificity: | Appears to be specific for TRPC4. See also the immunogen. |
| Cross Reactivity: | Rat, mouse. Other species not yet tested. See also the immunogen. |
| Packaging: | 0.1 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. |
| Background: | FUNCTION: Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.; SUBUNIT: Isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR). Interacts with NHERF.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).; - TISSUE SPECIFICITY: Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer of olfactory bulb). Lower levels are detected in other tissues.; - TISSUE SPECIFICITY: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Sheep |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry , Western Blot 1:300 to 1:4000 |
| Species Summary: | Rt, Mu |
| Alternate Names: | anti-Short transient receptor potential channel 4 antibody, anti-TrpC4 antibody, anti-Trp4 antibody, anti-Capacitative calcium entry channel 1 antibody, anti-CCE1 antibody, anti-Trrp4 antibody, anti-Receptor-activated cation channel TRP4 antibody, anti-Trp-related protein 4 antibody, anti-hTrp-4 antibody, anti-hTrp4 antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Funayama M, et al. Brain Res. Mol. Brain Res. 43:259-266(1996). 2. Tang Y, et al. J. Biol. Chem. 275:37559-37564(2000). 3. Mori Y, et a. NeuroReport 9:507-515(1998). 4. Petersen C.C.H, et al. Biochem. J. 311:41-44(1995). 5. Freichel M, et al. Nat. Cell Biol. 3:121-127(2001). |
order or
more information: | company product webpage |