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| Catalog Code: | NB110-74992 |
| Product Name: | TRPC1 Antibody |
| Product Description: | Sheep Polyclonal anti-TRPC1 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | TRPC1_RAT ; TRPC1_MOUSE ; TRPC1_HUMAN |
| Immunogen: | A synthetic peptide as a part of rat, human, mouse, dog and chicken (and other species) TRPC1, conjugated to immunogenic carrier protein was used as the immunogen. |
| Specificity: | Appears to be specific for TRPC1. |
| Cross Reactivity: | Rat, mouse and human. Other species not yet tested. |
| Packaging: | 0.1 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. |
| Background: | FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.; SUBUNIT: Interacts with TRPC3. Interacts with ITPR3.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; TISSUE SPECIFICITY: Seems to be ubiquitous. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Sheep |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry , Western Blot 1:300 to 1:4000 |
| Species Summary: | Rt, Mu, Hu |
| Alternate Names: | anti-Short transient receptor potential channel 1 antibody, anti-TrpC1 antibody, anti-TRP-1 protein antibody, anti-Trp1 antibody, anti-Trrp1 antibody, anti-Trpc1 transient receptor potential cation channel antibody, anti-subfamily C antibody, anti-member 1 antibody, anti-Mtrp1 antibody, anti-Trp-related protein 1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Wang W, et al. Am. J. Physiol. 276:C969-C979(1999). 2. Zhu X, et al. FEBS Lett. 373:193-198(1995). 3. Wes P.D, et al. Proc. Natl. Acad. Sci. U.S.A. 92:9652-9656(1995). 4. Zitt C, et al. Neuron 16:1189-1196(1996). 5. Lockwich T.P, et al. J. Biol. Chem. 275:11934-11942(2000). |
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